This study uses the Delphi method and the expert scoring method, and then 30 senior administrators of high-tech manufacturing enterprises are invited in order to score the direct relationships of the independent variables on the target variables and the independent variables, and the independent variables in the form of interval number range. The score range is between (weakest) and (strongest). Matlab is used to simulate the causal relationships among variables, and the calculation results of the center degree and the reason degree of DEMATEL are obtained, as shown in Table 3. The ranking results of DEMATEL verifies the theoretical hypothesis from 1 to 3 preliminarily. Table 3 shows that the simmelian ties are the centrality variable and the causal variable, and the high performance work practice system is the outcome variable. For the target variable (dependent variable) of knowledge fermenting, the high performance work practice system is the centrality variable and the causal variable, the knowledge fermenting is the outcome variable. Finally, for the target variable (dependent variable) of knowledge spiral, the knowledge fermenting is the centrality variable and the causal variable, and the knowledge spiral is the outcome variable.